Roles of nitric oxide, carbon monoxide, and hydrogen sulfide in the regulation of the hypothalamic-pituitary-adrenal axis.
作者： Cesare Mancuso , Pierluigi Navarra , Paolo Preziosi
DOI: 10.1111/J.1471-4159.2010.06606.X
关键词:
摘要: The importance of stress in modifying human behavior and lifestyle is no longer a matter debate. Although mild enhances the immune response prevents infections, prolonged seems to play pathogenic roles depression neurodegenerative disorders. body has developed an adaptive consisting cardiovascular, metabolic, psychological changes, which act concert eliminate stressors. One major components this hypothalamic-pituitary-adrenal axis, also known as axis. Over last 30 years, many studies have documented integrated stress-axis regulation by neurotransmitters. They demonstrated that gaseous neuromodulators, such NO, CO, H(2)S, regulate hypothalamic release neuropeptides. specific effects (stimulatory vs. inhibitory) these gases on axis varies, depending type (neurogenic or immuno-inflammatory), its intensity (low high), species studied (rodents humans). This review examines complex H(2)S modulation activity, with particular emphasis regulatory they exert at level.
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