Brain edema after intracerebral hemorrhage in rats: the role of iron overload and aquaporin 4.
作者： Wang Gai Qing , Yang Qi Dong , Tang Qing Ping , Li Guang Lai , Li Dong Fang
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摘要: Object Brain edema formation following intracerebral hemorrhage (ICH) appears to be partly related erythrocyte lysis and hemoglobin release. An increase of brain water content was associated with an iron, which is degradation product. Expression AQP4 highly modified in several disorders, it can play a key role cerebral formation. However, the question whether regulated by drugs lacks reliable evidence, interacting roles iron overload after ICH are unknown. The goal this study clarify relationship between expression characterize effects chelator deferoxamine (DFO) on delayed experimental ICH. Methods A total 144 Sprague-Dawley rats weighing 250 300 g were used work. animals randomly divided into 4 groups. models (Group C) generated injecting 100 μl autologous blood stereotacticall...
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