A macrophage phenotype for a constitutive, class II antigen-expressing, human dermal perivascular dendritic cell

摘要: Abstract A previously uncharacterized population of class II antigen-bearing dendritic cells that are intimately associated with the dermal microvasculature was identified in normal human skin using a double-label, indirect immunofluorescence technique. The only other major HLA-DR positive cell type noted these studies, microvascular endothelial (DMVEC), appeared to express lesser amounts region gene product than did this perivascular (DPDC). These DPDC were particularly common around small vessels superficial vascular plexus papillary dermis and distinct from mast cell, another normally seen similar location. Phenotypic ultrastructural studies have determined is more closely related monocyte/macrophage lineage lineage. location phenotype distinguishes it described constitutive types such as classic "histiocyte", veiled dendrocyte. relatively rich expression all three HLA-D products by macrophage would suggest could play significant role immunobiology unit.