Role of Gap Junctions and Hemichannels in Parasitic Infections
作者： José Luis Vega , Mario Subiabre , Felipe Figueroa , Kurt Alex Schalper , Luis Osorio
DOI: 10.1155/2013/589130
关键词:
摘要: In vertebrates, connexins (Cxs) and pannexins (Panxs) are proteins that form gap junction channels and/or hemichannels located at cell-cell interfaces cell surface, respectively. Similar channel types formed by innexins in invertebrate cells. These serve as pathways for cellular communication coordinate diverse physiologic processes. However, it is known many acquired inherited diseases deregulate Cx Panx channels, condition frequently worsens the pathological state of vertebrates. Recent evidences suggest play a relevant role bacterial viral infections. Nonetheless, little about Cx- Panx-based parasitic infections this review, available data on changes induced summarized. Additionally, we describe recent findings possible roles Finally, possibility new therapeutic designs based hemichannel blokers presented.
hindawi.com参考文章(123)
Juan A. Orellana, Helmuth A. Sánchez, Kurt A. Schalper, Vania Figueroa, Juan C. Sáez, Regulation of Intercellular Calcium Signaling Through Calcium Interactions with Connexin-Based Channels Advances in Experimental Medicine and Biology. ,vol. 740, pp. 777- 794 ,(2012) , 10.1007/978-94-007-2888-2_34
Anderson W, Gugssa A, Baccetti B, Gebru S, Desta D, Murray S, Lee Cm, Co-culture of Trypanosoma musculi with spleen-derived adherent fibroblasts: possible transfer of small molecules via connexons. Journal of submicroscopic cytology and pathology. ,vol. 37, pp. 223- 229 ,(2005)
Silva Js, Rossi Ma, Permeability alteration of the sarcolemmal membrane, particularly at the site of macrophage contact, in experimental chronic Trypanosoma cruzi myocarditis in mice. International Journal of Experimental Pathology. ,vol. 71, pp. 545- 555 ,(1990)
Kaethe Willms, Lilia Robert, José Caro, Ultrastructure of smooth muscle, gap junctions and glycogen distribution in Taenia solium tapeworms from experimentally infected hamsters. Parasitology Research. ,vol. 89, pp. 308- 316 ,(2003) , 10.1007/S00436-002-0733-1
Chia-Hung Christine Hsiao, N. Luisa Hiller, Kasturi Haldar, Laura J. Knoll, A HT/PEXEL motif in Toxoplasma dense granule proteins is a signal for protein cleavage but not export into the host cell. Traffic. ,vol. 14, pp. 519- 531 ,(2013) , 10.1111/TRA.12049
G J Leitch, M Scanlon, A Shaw, G S Visvesvara, S Wallace, Use of a fluorescent probe to assess the activities of candidate agents against intracellular forms of Encephalitozoon microsporidia. Antimicrobial Agents and Chemotherapy. ,vol. 41, pp. 337- 344 ,(1997) , 10.1128/AAC.41.2.337
Daniel Adesse, Regina Coeli Goldenberg, Fabio S Fortes, Dumitru A Iacobas, Sanda Iacobas, Antonio Carlos Campos de Carvalho, Maria de Narareth Meirelles, Huan Huang, Milena B Soares, Herbert B Tanowitz, Luciana Ribeiro Garzoni, David C Spray, None, Gap junctions and chagas disease. Advances in Parasitology. ,vol. 76, pp. 63- 81 ,(2011) , 10.1016/B978-0-12-385895-5.00003-7
Sanjay A. Desai, Sergey M. Bezrukov, Joshua Zimmerberg, A voltage-dependent channel involved in nutrient uptake by red blood cells infected with the malaria parasite. Nature. ,vol. 406, pp. 1001- 1005 ,(2000) , 10.1038/35023000
K. Kirk, H.A. Horner, B.C. Elford, J.C. Ellory, C.I. Newbold, Transport of diverse substrates into malaria-infected erythrocytes via a pathway showing functional characteristics of a chloride channel. Journal of Biological Chemistry. ,vol. 269, pp. 3339- 3347 ,(1994) , 10.1016/S0021-9258(17)41868-0
Raul Elgueta, Jaime A. Tobar, Kenji F. Shoji, Jaime De Calisto, Alexis M. Kalergis, Maria R. Bono, Mario Rosemblatt, Juan C. Sáez, Gap Junctions at the Dendritic Cell-T Cell Interface Are Key Elements for Antigen-Dependent T Cell Activation Journal of Immunology. ,vol. 183, pp. 277- 284 ,(2009) , 10.4049/JIMMUNOL.0801854