Role of selective alpha1 blockers in the therapy of hypertension

摘要: Abstract As millions more patients with mild hypertension are being brought into active drug therapy, the need for effective medications that safe long-term use has increased. This is, in part, as a result of adverse effect on coronary heart disease mortality observed two major therapeutic trials, Oslo Study and Multiple Risk Factor Intervention Trial. In both these, diuretic-first, stepped-care approach was used. Administration diuretics is frequently associated such biochemical abnormalities hypokalemia, hypercholesterolemia, hyperglycemia. Thus, wisdom routine diuretic first choice therapy questioned. Alternative drugs initial include beta blockers selective alpha 1 blockers. With blockers, there tendency serum triglycerides to increase high-density lipoprotein cholesterol decline, well an undesirable reduction cardiac output peripheral resistance. Selective because they lower blood pressure hemodynamically favorable manner have improve lipid profile, becoming increasingly attractive also part combination needed severe disease. The results noted new blocker terazosin strongly support its addition list preferred therapy.