Preparative chromatography with supercritical fluids. Comparison of simulated moving bed and batch processes.

摘要: Abstract Preparative chromatography is a key technology for the separation of fine chemicals in production scale. Most published studies are carried out using liquid solvents as mobile phase. However, used organic can often be replaced by supercritical fluids. A reduction or renouncement does not only correspond to trend so-called green chemistry —a sustainable, environmentally friendly chemical products. But changeover with fluids also reasonable under economic criteria. In this contribution comparison between Batch-supercritical fluid (Batch-SFC) process and simulated moving bed (SMB)-SFC presented. Because minor importance solvent consumption recovery SFC, systems were optimized primarily terms their specific productivity. For three four investigated model systems, productivity SMB significantly higher than Batch process. Due fact, that inevitably more economical process, supplementary costs considered. Therefore two processes was done from an point view considering minimum product price has realized fulfill defined aim. It found although productivities profitable rate range 0.4 5 t/a.