Role of Erythropoietin in Cerebral Glioma: An Innovative Target in Neuro-Oncology.

摘要: Background Erythropoietin (EPO) is a cytokine primarily involved in the regulation of erythropoiesis. In response to hypoxia–ischemia, hypoxia-inducible factor 1 induces EPO production, which, turn, inhibits apoptosis erythroid progenitor cells. By same mechanism and acting through other signaling pathways, exerts neuroprotective effects. Increased resistance hypoxia decreased are thought be important mechanisms for tumor progression, including malignant glioma. Because recent studies have demonstrated that its receptor (EPOR) expressed several tumors can promote growth, present study, we investigated EPOR expression human glioma effect administration rat model implantation. Methods Using Western blotting immunohistochemical analysis, examined EPO, EPOR, platelet endothelial cell adhesion molecule, Ki-67 specimens experimentally induced rats. experimental setting, daily dose recombinant (rHuEPO) or saline solution were administered 21 days Fischer rats subjected 9L line Results both animal specimens, found an increase as long lesion presented with increasing pattern. A significant direct correlation was between molecule low- high-grade gliomas. The treated rHuEPO significantly larger spread compared saline-treated Conclusions results our study shown EPO/EPOR complex might play role aggressive behavior rHuEPO-treated suggests feasible aggressiveness progression