摘要: Monozyten und Leukozyten interagieren mit dem Hamostasesystem uber verschiedene Mechanismen. Aktivierte konnen das plasmatische Gerinnungssystem durch die Expression von Tissue Factor aktivieren. Die daraus resultierende Fibrinbildung tragt dazu bei, den Entzundungsprozess zu begrenzen, behindert Ausbreitung Bakterien anderen Krankheitserregern. Durch direkten zellularen Kontakt Endothelzellen aktivieren eine prokoagulatorische Antwort induzieren. Dies wird Sezernierung Zytokinen proinflammatorischen Mediatoren verstarkt, neben der Endothelzellaktivierung hepatische Synthese Gerinnungsfaktoren stimulieren konnen. Weiterhin sind Hauptquelle fur Bildung an reichen Mikropartikeln. Diese ermoglichen Aufrechterhaltung einer basalen Gerinnungsaktivierung, in Gerinnselbildung involviert spielen wahrscheinlich wichtige Rolle Pathogenese thromboembolischen Prozessen.
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