Helicobacter pylori and gastritis: Untangling a complex relationship 27 years on

摘要: Since its' introduction by Warren and Marshall 27 years ago, Helicobacter pylori (HP) has become the linchpin in our understanding of important gastric conditions including gastritis, intestinal metaplasia (IM), gastric/duodenal ulcers (GU/DU), Mucosal Associated Lymphoid Tumour (MALToma) cancer. Initially named Campylobacter pyloridis, it was re-named HP when biochemical genetic characterization organism showed that not a member genus. The finding 1983 seminal. It is now recognized most common chronic human bacterial infection cause gastritis. strongly implicated development peptic ulcer disease neoplasms. In since discovery, much headway been made this ubiquitous had remained elusive, with work focused on eradication, part driven pharmaceutical research development. Standard triple therapy emerged to eradicate HP. However, emergence resistance, newer regimes have put forth include quadruple therapy, sequential dizzying array other combinations bent eradicating Much less known about natural history HP, different faces internationally, eradication its effect IM, GU/DU This review will address changing face 2011.