Analysis of the vacA, cagA, cagE, iceA, and babA2 genes in Helicobacter pylori from sixty-one pediatric patients from the Midwestern United States.
作者： Raymond P. Podzorski , Diane S. Podzorski , Ann Wuerth , Vasundhara Tolia
DOI: 10.1016/S0732-8893(03)00034-8
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摘要: Abstract This study was designed to characterize H. pylori from pediatric gastric biopsy specimens in terms of several genes (vacA, cagA, cagE, iceA1, iceA2, and babA2) proposed be involved the pathogenesis this organism. Many these have been studied adult isolates, however, not well characterized children. Using PCR we observed that 44% our biopsies shared two common genotypes ( vacA s1b m1, iceA2 ± babA2 ). While 26% had unique genotypes. The cag pathogenicity island associated genes, cagA were found together 64% or pylori, while 84% positive. presence gene has with a higher risk related diseases, only 36% contained gene.
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