Strategies for Fine-Tuning the Conformations of Cyclic Peptides.

作者: Rasha Jwad , Daniel Weissberger , Luke Hunter

DOI: 10.1021/ACS.CHEMREV.0C00013

关键词:

摘要: … peptide science is that the conformation of the RGD segment … peptides was found to correlate with lower oral bioavailability… homogeneous cyclic peptide with potent biological activity. …

参考文章(396)
Jayanta Chatterjee, Dale Mierke, Horst Kessler, N-methylated cyclic pentaalanine peptides as template structures. Journal of the American Chemical Society. ,vol. 128, pp. 15164- 15172 ,(2006) , 10.1021/JA063123D
Dieter Seebach, Olivier Bezençon, Bernhard Jaun, Thomas Pietzonka, Jennifer L. Matthews, Florian N. M. Kühnle, W. Bernd Schweizer, Further C‐Alkylations of Cyclotetrapeptides via Lithium and Phosphazenium (P4) Enolates: Discovery of a New Conformation Helvetica Chimica Acta. ,vol. 79, pp. 588- 608 ,(1996) , 10.1002/HLCA.19960790303
Justin S. Quartararo, Pianpian Wu, Joshua A. Kritzer, Peptide bicycles that inhibit the Grb2 SH2 domain. ChemBioChem. ,vol. 13, pp. 1490- 1496 ,(2012) , 10.1002/CBIC.201200175
Horst Kessler, Detection of Hindered Rotation and Inversion by NMR Spectroscopy Angewandte Chemie International Edition in English. ,vol. 9, pp. 219- 235 ,(1970) , 10.1002/ANIE.197002191
Danielle Skropeta, Katrina A. Jolliffe, Peter Turner, Pseudoprolines as removable turn inducers: tools for the cyclization of small peptides. Journal of Organic Chemistry. ,vol. 69, pp. 8804- 8809 ,(2004) , 10.1021/JO0484732
Pilar Forns, Jordi Piró, Carmen Cuevas, Mònica García, Mario Rubiralta, Ernest Giralt, Anna Diez, Constrained Derivatives of Stylostatin 1. 1. Synthesis and Biological Evaluation as Potential Anticancer Agents Journal of Medicinal Chemistry. ,vol. 46, pp. 5825- 5833 ,(2003) , 10.1021/JM030943H
Raymond Behrendt, Michaela Schenk, Hans-Jürgen Musiol, Luis Moroder, Photomodulation of conformational states. Synthesis of cyclic peptides with backbone-azobenzene moieties. Journal of Peptide Science. ,vol. 5, pp. 519- 529 ,(1999) , 10.1002/(SICI)1099-1387(199911)5:11<519::AID-PSC223>3.0.CO;2-3
Roland Haubner, Rainer Gratias, Beate Diefenbach, Simon L. Goodman, Alfred Jonczyk, Horst Kessler, Structural and Functional Aspects of RGD-Containing Cyclic Pentapeptides as Highly Potent and Selective Integrin αVβ3 Antagonists Journal of the American Chemical Society. ,vol. 118, pp. 7461- 7472 ,(1996) , 10.1021/JA9603721
Kazuki Sato, Ukon Nagai, Synthesis and antibiotic activity of a gramicidin S analogue containing bicyclic β-turn dipeptides Journal of The Chemical Society-perkin Transactions 1. ,vol. 17, pp. 1231- 1234 ,(1986) , 10.1039/P19860001231