Evolution of surface activity related functions of vertebrate pulmonary surfactant.

作者: Christopher B. Daniels , Olga V. Lopatko , Sandra Orgeig

DOI: 10.1111/J.1440-1681.1998.TB02283.X

关键词:

摘要: SUMMARY 1. Pulmonary surfactant is a mixture of lipids and proteins that lines the air-liquid interface lungs all vertebrates. In mammals, it functions to reduce vary surface tension, which helps decrease work breathing, provide alveolar stability prevent oedema. The present review examines evolution relative importance these activity related in vertebrates. 2. from fish, amphibians, birds most reptiles generally very low, correlating with low body temperature disaturated phospholipid content their surfactant. contrast, those higher preferred temperature, as well has much activity. 3. two main mammals are increase compliance relatively stiff bronchoalveolar lung. As respiratory units non-mammalian vertebrates up 1000-fold larger 100-fold more compliant, not required for functions. 4. non-mammals, appears act an anti-glue preventing adhesion surfaces may occur when collapse (e.g. during diving, swallowing prey or on expiration). Surfactant also controls lung fluid balance. These can be fulfilled by represent primitive active material vertebrate lungs.

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