Impact of mating behaviour on the success of malaria control through a single inundative release of transgenic mosquitoes.

摘要: Transgenic mosquitoes are a potential tool for the control or eradication of insect-vectored diseases. For malaria, one possible strategy relies on introduction malaria-refractory transgenes into wild Anopheles mosquito populations that would limit their capacity to transmit disease. The success such an approach obviously depends variety factors. By developing model integrates both population genetics and epidemiology, we explore how mating preferences cost efficacy refractoriness affects long-term prevalence malaria in humans subsequent single generation inundative release male transgenic mosquitoes. As may be intuitively expected, discrimination by wild-type individuals against ones generally reduces probability become stably established at high frequency populations. We also show circumstances where exhibit some degree individuals, this can favour spread refractory alleles lead significant reduction human (if dominant mechanism exceeds least 75%). existence non-intuitive outcome highlights practical value increasing understanding as means harness them implementation replacement approaches. Potential strategies which previously described gambiae could exploited manipulate mate choice stocks discussed.