Candidate tumour suppressor LUCA-15 can regulate multiple apoptotic pathways.
作者： M. Mourtada-Maarabouni , L. C. Sutherland , G. T. Williams
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摘要: Functional screening of a human bone marrow cDNA library for suppressors CD95-mediated apoptosis has led to the identification 326 bp fragment (Je2), which not only suppresses CD95-induced in Jurkat T-cells, but maps 3p21.3, an intronic region candidate TSG LUCA-15 locus. Here we report that overexpression Je2 CEM-C7 T-cell line is able suppress apoptosis, and induced by TNFα glucocorticoid analogue dexamethasone, was death topoisomerase II inhibitor etoposide. inhibition also associated with change pattern expression LUCA-15-encoded proteins. might therefore function inhibit destabilising message promoting degradation its RNA protein. This suppression appears be up-regulation inhibitory protein Bcl-xL. study confirms selective cell further implicates gene locus control apoptosis.
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