Acquisition of remifentanil self-administration: Enhanced in female rats but no effect of adolescent stress exposure.

摘要: Abstract Animal models of acquisition have been vital in shaping our understanding vulnerability factors that influence susceptibility to drugs abuse. Decades research substantiates a number biological, environmental, and behavioral predict – many which important the development early intervention efforts humans. The goal present study was examine synthetic opioid derivative 66 adult male female Long-Evans rats following histories stress exposure during adolescence. Stress-exposed were subjected mild paradigm, included alternating fox feces physical restraint for eight days. Following induction assessment, all implanted with intravenous catheters order self-administer remifentanil (1 μm/kg/infusion) no prior operant training. Acquisition self-administration measured over 15 days. Findings indicate regardless condition, acquired sooner emitted more active lever presses than males. Stress exposed animals exhibited increased anxiety-like response compared control group stress, operationalized as decreased exploratory behavior on an Elevated Plus Maze. However, these effects not expressed significant differences by stress. Together, findings sex are evident self-administration.