Kinetics of emitted mass—A study with three dry powder inhaler devices
作者： Srinivas Ravindra Babu Behara , Paul Kippax , Ian Larson , David A.V. Morton , Peter Stewart
DOI: 10.1016/J.CES.2011.07.029
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摘要: Abstract The purpose of this study was to understand the kinetics emptying micronised salbutamol sulphate (SS) and lactohale 300 (LH300) under varying air flow rates (30–180 L min −1 ) from three dry powder inhaler devices, Rotahaler ® (RH), Monodose Inhaler (MI) Handihaler (HH). Aerosol concentration vs. time profiles, determined through real-time laser diffraction particle sizing, demonstrated that majority RH emitted within one second while a more prolonged aerosolisation observed MI HH. Peak aerosol concentrations were achieved rapidly compared for both SS LH300. Calculated cumulative mass (CCEM) profiles obtained rate CCEM ( k ), estimated modelling approach, increased with increasing rates. LH300 significantly different at high highest lowest MI. Differences in between devices related capsule aperture size differences materials due bed structure. This approach provided an understanding which emptied proposed be powerful development tool future inhalers.
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sci-hub.se 参考文章(16)
M S Coates, D F Fletcher, H-K Chan, Judy A Raper, Simulation of the Performance of a Dry Powder Inhaler Using Computational Fluid Dynamics ,(2006)
Peter R. Byron, Respiratory Drug Delivery ,(1989)
M Coates, D F Fletcher, H-K Chan, Judy A Raper, A Comparative Study of Two Marketed Pulmonary Drug Delivery Devices Using Computational Fluid Dynamics pp. 821- 824 ,(2004)
T. Srichana, G.P. Martin, C. Marriott, Dry powder inhalers: The influence of device resistance and powder formulation on drug and lactose deposition in vitro European Journal of Pharmaceutical Sciences. ,vol. 7, pp. 73- 80 ,(1998) , 10.1016/S0928-0987(98)00008-6
B.J. MEAKIN, D. GANDERTON, I. PANZA, P. VENTURA, The effect of flow rate on drug delivery from the pulvinal, a high-resistance dry powder inhaler Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung. ,vol. 11, pp. 143- 152 ,(1998) , 10.1089/JAM.1998.11.143
Srinivas Ravindra Babu Behara, Ian Larson, Paul Kippax, David A.V. Morton, Peter Stewart, An approach to characterising the cohesive behaviour of powders using a flow titration aerosolisation based methodology Chemical Engineering Science. ,vol. 66, pp. 1640- 1648 ,(2011) , 10.1016/J.CES.2010.12.044
Matthew S. Coates, David F. Fletcher, Hak-Kim Chan, Judy A. Raper, The Role of Capsule on the Performance of a Dry Powder Inhaler Using Computational and Experimental Analyses Pharmaceutical Research. ,vol. 22, pp. 923- 932 ,(2005) , 10.1007/S11095-005-4587-Y
Beverley Alway, Roongtawan Sangchantra, Peter J. Stewart, Modelling the dissolution of diazepam in lactose interactive mixtures International Journal of Pharmaceutics. ,vol. 130, pp. 213- 224 ,(1996) , 10.1016/0378-5173(95)04303-9
Nora Y.K. Chew, Hak-Kim Chan, David F. Bagster, Jay Mukhraiya, Characterization of pharmaceutical powder inhalers: estimation of energy input for powder dispersion and effect of capsule device configuration Journal of Aerosol Science. ,vol. 33, pp. 999- 1008 ,(2002) , 10.1016/S0021-8502(02)00059-9
Norman Richard Draper, Harry Smith, Applied Regression Analysis ,(1966)