Distribution of Allotypic Specificities A1, A2, A14, and A15 Among Immunoglobulin G Molecules

摘要: The distribution of specificities A1, A2 (Fd-associated allotypes rabbit heavy chains), A14 and A15 (Fc-associated γ chains) was studied using 125 I-labeled IgG from homozygous heterozygous rabbits known pedigree. an 14/A2, 15 whose pedigree showed that A1 genetically associated with had closely similar proportions these two (80%), whereas 15/A2, 14 in coupling equal (20%). A suppressed phenotypic expression the allotype also for to which it coupled. quantitative Fc (A14 or A15) is influenced by Fd associated. binding experiments indicated genetic association between faithfully reproduced at least 90% 95% chains a search “recombinant” molecules (A1 heterozygote) negative within limits method (5% 10%). Although preliminary report (1) suggested such did occur, low figures seem indicate formation utilize information region one homologous chromosome other cannot play major role generating diversity antibody chains.