Retinoic Acids Promote the Repair of the Dermal Damage and the Effacement of Wrinkles in the UVB-Irradiated Hairles Mouse

摘要: Chronic irradiation of hairless mice with UVB leads to elastosis as evidenced by both histologic means and an increase in skin desmosine content. Treatment topical all-trans- or 13-cis-retinoic acid causes dose-dependent increments the area dermal "repair zone"; content increases during but does not change significantly after is discontinued retinoic treatment commenced. During course animals develop permanent wrinkles on exposed dorsal surface, which can be recorded plastic impressions. The extent wrinkling quantitated it has been demonstrated that topically applied acids lead complete effacement these surface features process appears permanent.