摘要: Cushing’s syndrome (CS) results from prolonged exposure of tissues to excess glucocorticoids. After Harvey Cushing’ s initial report in the early 20th century (1), CS has been etiologically subdivided into adenocorticotropin hormone (ACTH)-independent (nonpituitary) or ACTH-dependent (2–4). Endogenous is rare, with an overall incidence approx two four new cases per million population year. accounts for 85% endogenous cases. In majority these (80%), cause autonomous pituitary ACTH secretion and referred as disease (CD). remaining 20%, source ectopic. CD a female male preponderance (8/1), whereas ectopic more common men (3/1). Ectopic corticotropin-releasing (CRH) production causing also described 11 (5–7). this chapter, we focus on diagnosis treatment which generally presents between second sixth decades life, peak at age 35 yr (2).
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D.L. Fraker, G.P. Chrousos, H.I. Pass, G.B. Cutler, J.A. Norton, L.K. Nieman, M.A. Zeiger, Effective reversibility of the signs and symptoms of hypercortisolism by bilateral adrenalectomy Surgery. ,vol. 114, pp. 1138- 1143 ,(1993) , 10.5555/URI:PII:003960609390335B
Chrousos Gp, Nieman Lk, Doherty Gm, Cutler Gb, Norton Ja, Time to recovery of the hypothalamic-pituitary-adrenal axis after curative resection of adrenal tumors in patients with Cushing's syndrome. Surgery. ,vol. 108, pp. 1085- 1090 ,(1990)
George Mastorakos, George P. Chrousos, Theodore C. Friedman, Mark H. Scott, Muriel I. Kaiser-Kupfer, Evrydiki A. Bouzas, Posterior subcapsular cataract in endogenous Cushing syndrome: an uncommon manifestation. Investigative Ophthalmology & Visual Science. ,vol. 34, pp. 3497- 3500 ,(1993)
Beverly M.K. Biller, Pathogenesis of Pituitary Cushing’s Syndrome: Pituitary Versus Hypothalamic Endocrinology and Metabolism Clinics of North America. ,vol. 23, pp. 547- 554 ,(1994) , 10.1016/S0889-8529(18)30083-5
M Karl, T Kino, N E Huizenga, B R Haddad, M R Hughes, G P Chrousos, S W Lamberts, D A Katz, J W Koper, Cushing's disease preceded by generalized glucocorticoid resistance: clinical consequences of a novel, dominant-negative glucocorticoid receptor mutation. Proceedings of the Association of American Physicians. ,vol. 108, pp. 296- 307 ,(1996)
Jack A. Yanovski, Gordon B. Cutler, Glucocorticoid Action and the Clinical Features of Cushing’s Syndrome Endocrinology and Metabolism Clinics of North America. ,vol. 23, pp. 487- 509 ,(1994) , 10.1016/S0889-8529(18)30080-X
ACTH-PRODUCING PITUITARY TUMORS FOLLOWING ADRENALECTOMY FOR CUSHING'S SYNDROME Annals of Internal Medicine. ,vol. 52, pp. 560- 569 ,(1960) , 10.7326/0003-4819-52-3-560
Charles B. Wilson, A decade of pituitary microsurgery. The Herbert Olivecrona lecture. Journal of Neurosurgery. ,vol. 61, pp. 814- 833 ,(1984) , 10.3171/JNS.1984.61.5.0814
J.C. Ganz, Gamma Knife Treatment of Pituitary Adenomas Stereotactic and Functional Neurosurgery. ,vol. 64, pp. 3- 10 ,(1995) , 10.1159/000098758
Hypopituitarism following external radiotherapy for pituitary tumours in adults. QJM: An International Journal of Medicine. ,vol. 70, pp. 145- 160 ,(1989) , 10.1093/OXFORDJOURNALS.QJMED.A068308