Chancen und Risiken der blutbasierten molekularpathologischen Analytik zirkulierender Tumorzellen (CTC) und zellfreier DNA (cfDNA) in der personalisierten Krebstherapie

Zbigniew T. Czyż, Martin Hoffmann, Günter Schlimok, Bernhard Polzer, Christoph A. Klein, Reliable Single Cell Array CGH for Clinical Samples PLoS ONE. ,vol. 9, pp. e85907- ,(2014) , 10.1371/JOURNAL.PONE.0085907

T. Fehm, W. Sauerbrei, Information from CTC measurements for metastatic breast cancer prognosis—we should do more than selecting an “optimal cut point” Breast Cancer Research and Treatment. ,vol. 122, pp. 219- 220 ,(2010) , 10.1007/S10549-010-0762-X

V. Plaks, C. D. Koopman, Z. Werb, Circulating Tumor Cells Science. ,vol. 341, pp. 1186- 1188 ,(2013) , 10.1126/SCIENCE.1235226

Frank Diehl, Meng Li, Yiping He, Kenneth W Kinzler, Bert Vogelstein, Devin Dressman, BEAMing: single-molecule PCR on microparticles in water-in-oil emulsions Nature Methods. ,vol. 3, pp. 551- 559 ,(2006) , 10.1038/NMETH898

Nikolas H. Stoecklein, Christoph A. Klein, Genetic disparity between primary tumours, disseminated tumour cells, and manifest metastasis. International Journal of Cancer. ,vol. 126, pp. 589- 598 ,(2010) , 10.1002/IJC.24916

F. Diehl, M. Li, D. Dressman, Y. He, D. Shen, S. Szabo, L. A. Diaz, S. N. Goodman, K. A. David, H. Juhl, K. W. Kinzler, B. Vogelstein, Detection and quantification of mutations in the plasma of patients with colorectal tumors. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 102, pp. 16368- 16373 ,(2005) , 10.1073/PNAS.0507904102

Luis A. Diaz, Alberto Bardelli, Liquid Biopsies: Genotyping Circulating Tumor DNA Journal of Clinical Oncology. ,vol. 32, pp. 579- 586 ,(2014) , 10.1200/JCO.2012.45.2011

Christoph A. Klein, Selection and adaptation during metastatic cancer progression Nature. ,vol. 501, pp. 365- 372 ,(2013) , 10.1038/NATURE12628

M. Ilie, E. Long, C. Butori, V. Hofman, C. Coelle, V. Mauro, K. Zahaf, C.H. Marquette, J. Mouroux, P. Paterlini-Bréchot, P. Hofman, ALK-gene rearrangement: a comparative analysis on circulating tumour cells and tumour tissue from patients with lung adenocarcinoma Annals of Oncology. ,vol. 23, pp. 2907- 2913 ,(2012) , 10.1093/ANNONC/MDS137

Nuh N. Rahbari, Ulrich Bork, Alexandra Kircher, Thomas Nimitz, Sebastian Schölch, Christoph Kahlert, Thomas Schmidt, Gunnar Steinert, Alexis B. Ulrich, Christoph Reissfelder, Markus W. Büchler, Moritz Koch, Jürgen Weitz, Compartmental differences of circulating tumor cells in colorectal cancer. Annals of Surgical Oncology. ,vol. 19, pp. 2195- 2202 ,(2012) , 10.1245/S10434-011-2178-1