Selective inhibitors of the FK506-binding protein 51 by induced fit
作者： Steffen Gaali , Alexander Kirschner , Serena Cuboni , Jakob Hartmann , Christian Kozany
关键词:
摘要: … During the development of ligand 1 we noticed that the close analogs iFit1 (2) and iFit2 (3) … ligands, have been pursued for neurological disorders owing to their reported neuroactive …
rcsb.org
mpg.de
nature.com
researchgate.net 参考文章(55)
Jakob Hartmann, Klaus V. Wagner, Claudia Liebl, Sebastian H. Scharf, Xiao-Dong Wang, Miriam Wolf, Felix Hausch, Theo Rein, Ulrike Schmidt, Chadi Touma, Joyce Cheung-Flynn, Marc B. Cox, David F. Smith, Florian Holsboer, Marianne B. Müller, Mathias V. Schmidt, The involvement of FK506-binding protein 51 (FKBP5) in the behavioral and neuroendocrine effects of chronic social defeat stress. Neuropharmacology. ,vol. 62, pp. 332- 339 ,(2012) , 10.1016/J.NEUROPHARM.2011.07.041
Eléonore Beurel, Laurie E. Harrington, Richard S. Jope, Inflammatory T Helper 17 Cells Promote Depression-like Behavior in Mice Biological Psychiatry. ,vol. 73, pp. 622- 630 ,(2013) , 10.1016/J.BIOPSYCH.2012.09.021
C. Touma, Stress and Affective Disorders: Animal Models Elucidating the Molecular Basis of Neuroendocrine-Behavior Interactions Pharmacopsychiatry. ,vol. 44, ,(2011) , 10.1055/S-0031-1271702
Edwin R. Sanchez, Chaperoning steroidal physiology: Lessons from mouse genetic models of Hsp90 and its cochaperones Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. ,vol. 1823, pp. 722- 729 ,(2012) , 10.1016/J.BBAMCR.2011.11.006
Anne-Katrin Fabian, Andreas März, Sonja Neimanis, Ricardo M. Biondi, Christian Kozany, Felix Hausch, InterAKTions with FKBPs - Mutational and Pharmacological Exploration PLOS ONE. ,vol. 8, ,(2013) , 10.1371/JOURNAL.PONE.0057508
D. A. EVANS, M. D. ENNIS, T. LE, N. MANDEL, G. MANDEL, ASYMMETRIC ACYLATION REACTIONS OF CHIRAL IMIDE ENOLATES. THE FIRST DIRECT APPROACH TO THE CONSTRUCTION OF CHIRAL β‐DICARBONYL SYNTHONS ChemInform. ,vol. 15, ,(2002) , 10.1002/CHIN.198421215
Robert E Babine, J Ernest Villafranca, Bruce G Gold, FKBP immunophilin patents for neurological disorders Expert Opinion on Therapeutic Patents. ,vol. 15, pp. 555- 573 ,(2005) , 10.1517/13543776.15.5.555
Benjamin K. Attwood, Julie-Myrtille Bourgognon, Satyam Patel, Mariusz Mucha, Emanuele Schiavon, Anna E. Skrzypiec, Kenneth W. Young, Sadao Shiosaka, Michal Korostynski, Marcin Piechota, Ryszard Przewlocki, Robert Pawlak, Neuropsin cleaves EphB2 in the amygdala to control anxiety Nature. ,vol. 473, pp. 372- 375 ,(2011) , 10.1038/NATURE09938
Joyce Cheung-Flynn, Viravan Prapapanich, Marc B. Cox, Daniel L. Riggs, Carlos Suarez-Quian, David F. Smith, Physiological Role for the Cochaperone FKBP52 in Androgen Receptor Signaling Molecular Endocrinology. ,vol. 19, pp. 1654- 1666 ,(2005) , 10.1210/ME.2005-0071
Alexander W. Schüttelkopf, Daan M. F. van Aalten, PRODRG: a tool for high-throughput crystallography of protein–ligand complexes Acta Crystallographica Section D-biological Crystallography. ,vol. 60, pp. 1355- 1363 ,(2004) , 10.1107/S0907444904011679