Rapid simultaneous determination of alkylxanthines by CZE and its application in analysis of pharmaceuticals and food samples
作者： Fiona Regan , Yuliya Shakalisava
DOI: 10.1016/J.ACA.2004.10.033
关键词:
摘要: AbstractCapillary electrophoresis (CE) offers the possibility of fast, cheap and reproducible separations for pharmaceutical preparations. Alkylx-anthines make up a family compounds that are used in treatment prevention bronchi asthma chronic pulmonary disease. Thegroup analysed include caffeine, dyphylline, theophylline, theobromine enprofylline. This paper shows simple capillaryzone electrophoretic (CZE) method separation this group xanthines. Using 20mM borate buffer at pH 9.4 as running 55 ◦ Citwas possible to complete total sample 2min. Limits detection range 1.9–2.5mgl −1 were achieved with %R.S.D.of 0.06–0.22% (n =5). The technique is applied samples containing analytes, including tablets chocolate. Reproducibility(%R.S.D.) chocolate analysis by CZE was less than 4.5%.© 2004 Elsevier B.V. All rights reserved. Keywords: Capillary zone elctrophoresis; Fast separation; Alkylxanthines; Chocolate
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