MYC as therapeutic target in leukemia and lymphoma

作者: Javier Leon , Maria G Cortiguera , Ana Batlle-López , Marta Albajar , M. Dolores Delgado

DOI: 10.2147/BLCTT.S60495

关键词:

摘要: MYC is a transcription factor that involved in the expression of many genes. Deregulated found about half human tumors, being more prevalent hematologi- cal neoplasms. Deregulation mechanisms include chromosomal translocation (particularly lymphoma), amplification, and hyperactivation transcription. Here we review involvement major types leukemia lymphoma. rearrangements appear all Burkitt lymphomas are common other lymphoma types, whereas acute lymphoblastic leukemia, myeloid lymphoproliferative, myeloproferative diseases, they less frequent. However, overexpression present hematological malignancies often correlates with worse prognosis. Data leukemia-derived cells animal models lymphomagenesis leukemogenesis suggest would be good therapeutic target. Several MYC-directed therapies have been assayed preclinical settings even clinical trials. First, peptides small molecules interrupt MYC-MAX interaction impair MYC- mediated tumorogenesis several mouse solid although not yet models. Second, there number inhibiting heterodimers DNA, still research phase. Third, inhibitors via inhibition BRD4 (a reader acetylated histones) shown to control growth MYC-transformed used clinic Finally, promising MYC-mediated synthetic lethal approaches

参考文章(172)
Zeping Wang, Nandini Bhattacharya, Matt Weaver, Kate Petersen, Maria Meyer, Leslie Gapter, Nancy S Magnuson, Pim-1: A serine/threonine kinase with a role in cell survival, proliferation, differentiation and tumorigenesis. Journal of Veterinary Science. ,vol. 2, pp. 167- 179 ,(2001) , 10.4142/JVS.2001.2.3.167
L Détivaud, C Doerig, L Meijer, N Gray, ATP-site directed inhibitors of cyclin-dependent kinases. Current Medicinal Chemistry. ,vol. 6, pp. 859- 875 ,(1999)
Christoph Bützler, Ian C. Nicholson, Xiangang Zou, Marianne Brüggemann, Concepción Palomo, B-Cell Tumorigenesis in Mice Carrying a Yeast Artificial Chromosome-based Immunoglobulin Heavy/c-myc Translocus Is Independent of the Heavy Chain Intron Enhancer (Eμ) Cancer Research. ,vol. 59, pp. 5625- 5628 ,(1999)
Lance R. Thomas, William P. Tansey, Proteolytic control of the oncoprotein transcription factor Myc. Advances in Cancer Research. ,vol. 110, pp. 77- 106 ,(2011) , 10.1016/B978-0-12-386469-7.00004-9
Rashmi Kanagal-Shamanna, L Jeffrey Medeiros, Gary Lu, Sa A Wang, John T Manning, Pei Lin, Gerald M Penn, Ken H Young, M James You, Francisco Vega, Roland Bassett, Roberto N Miranda, High‐grade B cell lymphoma, unclassifiable, with blastoid features: an unusual morphological subgroup associated frequently with BCL2 and/or MYC gene rearrangements and a poor prognosis Histopathology. ,vol. 61, pp. 945- 954 ,(2012) , 10.1111/J.1365-2559.2012.04301.X
Juan M. Caraballo, Juan C. Acosta, Miguel A. Cortés, Marta Albajar, M. Teresa Gómez-Casares, Ana Batlle-López, M. Angeles Cuadrado, Arantza Onaindia, Gabriel Bretones, Javier Llorca, Miguel A. Piris, Dolors Colomer, Javier León, High p27 protein levels in chronic lymphocytic leukemia are associated to low Myc and Skp2 expression, confer resistance to apoptosis and antagonize Myc effects on cell cycle. Oncotarget. ,vol. 5, pp. 4694- 4708 ,(2014) , 10.18632/ONCOTARGET.2100
Elias Campo, N Lee Harris, Elaine S Jaffe, Stefano A Pileri, Harald Stein, Jurgen Thiele, James W Vardiman, None, WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues ,(2017)
Andrea Rinaldi, Michael Mian, Ivo Kwee, Davide Rossi, Clara Deambrogi, Afua A. Mensah, Francesco Forconi, Valeria Spina, Emanuele Cencini, Daniela Drandi, Marco Ladetto, Rita Santachiara, Roberto Marasca, Valter Gattei, Franco Cavalli, Emanuele Zucca, Gianluca Gaidano, Francesco Bertoni, Genome-wide DNA profiling better defines the prognosis of chronic lymphocytic leukaemia. British Journal of Haematology. ,vol. 154, pp. 590- 599 ,(2011) , 10.1111/J.1365-2141.2011.08789.X
ZoltÁN Beck, Attila Bácsi, Eszter Kovács, JolÁN Kiss, Attila Kiss, ErzsÉBet Balogh, BÉLa Telek, Ferenc D. Tócute;th, IstvÁN Andirkócute;, éva Oláh, MiklÓcute;S Udvardy, Kalman Rak, Changes in Oncogene Expression Implicated in Evolution of Chronic Granulocytic Leukemia from its Chronic Phase to Acceleration Leukemia & Lymphoma. ,vol. 30, pp. 293- 306 ,(1998) , 10.3109/10428199809057542
David C. Linch, Burkitt lymphoma in adults. British Journal of Haematology. ,vol. 156, pp. 693- 703 ,(2012) , 10.1111/J.1365-2141.2011.08877.X