Digestive properties of the venom of the Australian Coastal Taipan, Oxyuranus scutellatus (Peters, 1867).
作者： Jay Nicholson , Peter Mirtschin , Frank Madaras , Michael Venning , Michael Kokkinn
DOI: 10.1016/J.TOXICON.2006.06.007
关键词:
摘要: Abstract The digestive properties of Australian elapid snake venoms have not been studied to any great extent. To address this, the in vitro Oxyuranus scutellatus (Australian Coastal Taipan) venom were investigated a simulation vivo conditions using parameters reported for stomach snakes and representative prey this species. amount soluble protein released was measured over time bicinchoninic acid (BCA) assay. Dismembered mouse hindlegs injected intramuscularly with 0.1 ml O. (concentration 10 mg/ml) maintained micro-anaerobic, acidic environment ( pH ≈ 1.2 –1.7) at 25 °C. bathing liquid sampled every 24 h 7 days, assayed protein. Statistical analysis revealed that increased rate which proteins when compared negative control suggesting potential importance envenomation digestion whole prey.
elsevier.com
sci-hub.se 参考文章(51)
A. L. Bieber, Metal and Nonprotein Constituents in Snake Venoms Springer Berlin Heidelberg. pp. 295- 306 ,(1979) , 10.1007/978-3-642-66913-2_9
Kurt F. Stocker, Medical Use of Snake Venom Proteins ,(1990)
Struan K. Sutherland, Australian animal toxins: The creatures, their toxins, and care of the poisoned patient ,(1983)
H.F. Deutsch, C.R. Diniz, Some proteolytic activities of snake venoms. Journal of Biological Chemistry. ,vol. 216, pp. 17- 26 ,(1955) , 10.1016/S0021-9258(19)52280-3
E.A. Dennis, Diversity of group types, regulation, and function of phospholipase A2. Journal of Biological Chemistry. ,vol. 269, pp. 13057- 13060 ,(1994) , 10.1016/S0021-9258(17)36794-7
Jan FOHLMAN, David EAKER, Evert KARLSSON, Stephen THESLEFF, Taipoxin, an Extremely Potent Presynaptic Neurotoxin from the Venom of the Australian Snake Taipan (Oxyuranus s. scutellatus) FEBS Journal. ,vol. 68, pp. 457- 469 ,(1976) , 10.1111/J.1432-1033.1976.TB10833.X
H Speijer, J W Govers-Riemslag, R F Zwaal, J Rosing, Prothrombin activation by an activator from the venom of Oxyuranus scutellatus (Taipan snake). Journal of Biological Chemistry. ,vol. 261, pp. 13258- 13267 ,(1986) , 10.1016/S0021-9258(18)69299-3
Chikahisa Takasaki, Fujiko Yutani, Tsuyoshi Kajiyashiki, Amino acid sequences of eight phospholipases A2 from the venom of Australian king brown snake, Pseudechis australis. Toxicon. ,vol. 28, pp. 329- 339 ,(1990) , 10.1016/0041-0101(90)90068-I
Miriam Kolko, Torben Bruhn, Thomas Christensen, Michel Lazdunski, Gérard Lambeau, Nicolas G. Bazan, Nils H. Diemer, Secretory phospholipase A2 potentiates glutamate-induced rat striatal neuronal cell death in vivo. Neuroscience Letters. ,vol. 274, pp. 167- 170 ,(1999) , 10.1016/S0304-3940(99)00709-0
Z.Emmanuel Selvanayagam, S.G Gnanavendhan, K.A Ganesh, D Rajagopal, P.V Subba Rao, ELISA for the detection of venoms from four medically important snakes of India. Toxicon. ,vol. 37, pp. 757- 770 ,(1999) , 10.1016/S0041-0101(98)00215-3