Resuscitation of the monkey brain after 1 h complete ischemia. I. Physiological and morphological observations.

摘要: Abstract In normothermic rhesus monkeys ( Macaca mulatta ) blood flow to the brain was completely interrupted for 1 h, and then restored different periods from 45 min 24 h. Neuronal function monitored by recording electrocorticogram (ECoG) pyramidal response (PR) electrical stimulation of motor cortex. addition, cerebral flow, intracranial pressure, epicortical pH, gases, glucose, hematocrit, coagulation times, serum electrolytes were repeatedly measured. During ischemia, ECoG suppressed within 15 sec, a few min. 11 out 19 animals PR — at survival times more than 90 electrocortical activity returned upon recirculation. 8 animal recovery neuronal did not occur, presumably because an impaired recirculation brain. Reduction in post-ischemic resulted combined effect swelling with consequent increased microcirculatory disturbances, hypotension. one case circulatory disturbance restricted circumscribed areas causing typical boundary zone lesions pallidum parietal lobe.