The evaluation of cognitive function in the dementias: methodological and regulatory considerations

摘要: Impairment of cognitive function is the central feature dementia. Although, clinically, deficit most often manifests itself as memory problems, a number other areas cognition are affected, and but one skills compromised in Dementia with Lewy bodies, for example, accounts 15% to 25% all dementias does not have deficits core feature. Our facilities underlie our abilities engage successfully activities daily living (ADL) it follows thai enhancement will facilitate performance ADL The assessment understanding these impairments crucial any treatment disorder. Unfortunately, principal instrument used assess major clinical trials Alzheimer's disease recent years, Disease Assessment Scale-Cognitive Subsection (ADAS-COG), primarily assesses aspects memory, which has resulted important dementia being overlooked. Automated tests now available that can identify an earlier onset improvements smaller samples than ADAS, Regulatory authorities should encourage - or even require use automated procedures alongside ADAS pivotal help determine relative utility instruments fairest way possible. Whatever outcome, this be long-term benefit patients, carers, drug developers, clinicians, regulators area.