It all began with Ronald Ross: 100 years of malaria research and control in Sierra Leone (1899-1999).

摘要: It was in Sierra Leone, 100 years ago 1899, that human malarial parasites were first observed wild-caught Anopheles gambiae and An. funestus, the principal vectors of malaria Africa. In same year, Ronald Ross initiated antilarval measures for control. This paper reviews field research control which became known as 'White Man's Grave' 19th century largely because high malaria-related mortality amongst Europeans living there. The establishment a laboratory Liverpool School Tropical Medicine Freetown 1920 made Leone centre Africa up to during Second World War. Eminent malariologists including Ross, Samuel Christophers, George Macdonald, Leonard Bruce-Chwatt, Brian Maegraith, Ian Macgregor, Greenwood Michael Service visited activities. review highlights tremendous efforts towards defining epidemiological picture disease most effective means combatting it. Malaria many other parts world, used be based on mosquito eradication. However, experience gained over past has shown is often not cost-effective areas where interruption transmission cannot sustained. Emphasis should now early diagnosis, treatment with antimalarials, selective use preventive vector insecticide-treated materials they can