The endocytic receptor megalin binds the iron transporting neutrophil-gelatinase-associated lipocalin with high affinity and mediates its cellular uptake
作者： Vibeke Hvidberg , Christian Jacobsen , Roland K. Strong , Jack B. Cowland , Søren K. Moestrup
DOI: 10.1016/J.FEBSLET.2004.12.031
关键词:
摘要: Neutrophil-gelatinase-associated lipocalin (NGAL) is a prominent protein of specific granules human neutrophils also synthesized by epithelial cells during inflammation. NGAL binds bacterial siderophores preventing bacteria from retrieving iron this source. Also, may be important in delivering to formation the tubular primordial kidney. No cellular receptor for has been described. We show here that megalin, member low-density lipoprotein family expressed polarized epithelia, with high affinity, as shown surface plasmon resonance analysis. Furthermore, rat yolk sac cell line known express levels endocytosed mechanism completely blocked an antibody against megalin.
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