The α2ß1 Integrin: Structure, Function, and Regulation of a Platelet Surface Collagen Receptor

摘要: Publisher Summary This chapter discusses the structure. function. and regulation of a platelet surface collagen receptor α 2 β 1 integrin. The integrin family adhesive receptors mediates cell substrate cell–cell properties many diverse types. that is identical to membrane glycoprotein Ia-IIa complex, serves as on platelets. has been purified, its structure elucidated, amino acid sequences both subunits deduced from cDNA sequences. function complex established studies purified reconstituted into liposomes, use inhibitory monoclonal antibodies, transfection expression by cells which it normally not expressed, study platelets deficient in expression. Recent evidence role under conditions flow. 5' regulatory region gene recently cloned elements confer megakaryocytic specific reporter constructs have identified.