Retention in Care and Outpatient Costs for Children Receiving Antiretroviral Therapy in Zambia: A Retrospective Cohort Analysis

作者: Callie A. Scott , Hari Iyer , Deophine Lembela Bwalya , Kelly McCoy , Gesine Meyer-Rath

DOI: 10.1371/JOURNAL.PONE.0067910

关键词:

摘要: Background There are few published estimates of the cost pediatric antiretroviral therapy (ART) in Africa. Our objective was to estimate outpatient providing ART children remaining care at six public sector clinics Zambia during first three years after initiation, stratified by service delivery site and time on treatment. Methods Data resource utilization (drugs, diagnostics, visits, fixed costs) treatment outcomes (in care, died, lost follow up) were extracted from medical records for 1,334 sites who initiated <15 age between 2006 2011. Fixed variable unit costs (reported 2011 USD) estimated provider’s perspective using level data. Results Median initiation 4.0 years; median CD4 percentage 14%. One year 73% patients remained ranging 60% 91% depending site. The average annual per patient $209 (95% CI, $199–$219), $116 $107–$126) $516 $499–$533) Average decreased as increased. Antiretroviral drugs largest component all (>50%) four sites. At two sites, visits together accounted >50% costs. distribution is slightly skewed, with 3% 13% lower than site. Conclusions Outpatient initiating low comparable reported adults. Outpatient retention vary widely site, suggesting opportunities efficiency gains. Taking advantage such will help ensure that targets coverage can be met.

参考文章(13)
John H. Bratt, Kwasi Torpey, Mushota Kabaso, Yebo Gondwe, Costs of HIV/AIDS outpatient services delivered through Zambian public health facilities Tropical Medicine & International Health. ,vol. 16, pp. 110- 118 ,(2011) , 10.1111/J.1365-3156.2010.02640.X
Gesine Meyer-Rath, Alana Brennan, Lawrence Long, Buyiswa Ndibongo, Karl Technau, Harry Moultrie, Lee Fairlie, Ashraf Coovadia, Sydney Rosen, None, Cost and outcomes of paediatric antiretroviral treatment in South Africa. AIDS. ,vol. 27, pp. 243- 250 ,(2013) , 10.1097/QAD.0B013E32835A5B92
Sydney Rosen, Lawrence Long, Ian Sanne, The outcomes and outpatient costs of different models of antiretroviral treatment delivery in South Africa. Tropical Medicine & International Health. ,vol. 13, pp. 1005- 1015 ,(2008) , 10.1111/J.1365-3156.2008.02114.X
James Kahn, E Marseille, MJ Giganti, A Mwango, A Chisembele-Taylor, L Mulenga, M Over, JG Kahn, JSA Stringer, Taking ART to Scale: Determinants of the Cost and Cost-Effectiveness of Antiretroviral Therapy in 45 Clinical Sites in Zambia PLoS ONE. ,vol. 7, pp. e51993- ,(2012) , 10.1371/JOURNAL.PONE.0051993
Janneke H. van Dijk, Catherine G. Sutcliffe, Bornface Munsanje, Pamela Sinywimaanzi, Francis Hamangaba, Philip E. Thuma, William J. Moss, HIV-Infected Children in Rural Zambia Achieve Good Immunologic and Virologic Outcomes Two Years after Initiating Antiretroviral Therapy PLoS ONE. ,vol. 6, pp. e19006- ,(2011) , 10.1371/JOURNAL.PONE.0019006
Omar Galárraga, Veronika J. Wirtz, Alejandro Figueroa-Lara, Yared Santa-Ana-Tellez, Ibrahima Coulibaly, Kirsi Viisainen, Antonieta Medina-Lara, Eline L. Korenromp, Unit Costs for Delivery of Antiretroviral Treatment and Prevention of Mother-to-Child Transmission of HIV PharmacoEconomics. ,vol. 29, pp. 579- 599 ,(2011) , 10.2165/11586120-000000000-00000
Heloisa Helena de Sousa Marques, Bernard François Couttolenc, Maria do Rosário Dias de Oliveira Latorre, Maria Zilda de Aquino, Maria Ignez Garcia Aveiro, Ana Maria Aratangy Pluciennik, Costs of care provided in a university hospital for children exposed to or infected with the HIV/AIDS Cadernos De Saude Publica. ,vol. 23, ,(2007) , 10.1590/S0102-311X2007001500008
Nicolas A. Menzies, Andres A. Berruti, Richard Berzon, Scott Filler, Robert Ferris, Tedd V. Ellerbrock, John M. Blandford, The cost of providing comprehensive HIV treatment in PEPFAR-supported programs. AIDS. ,vol. 25, pp. 1753- 1760 ,(2011) , 10.1097/QAD.0B013E3283463EEC
Carolyn Bolton-Moore, Mwangelwa Mubiana-Mbewe, Ronald A. Cantrell, Namwinga Chintu, Elizabeth M. Stringer, Benjamin H. Chi, Moses Sinkala, Chipepo Kankasa, Craig M. Wilson, Catherine M. Wilfert, Albert Mwango, Jens Levy, Elaine J. Abrams, Marc Bulterys, Jeffrey S. A. Stringer, Clinical Outcomes and CD4 Cell Response in Children Receiving Antiretroviral Therapy at Primary Health Care Facilities in Zambia JAMA. ,vol. 298, pp. 1888- 1899 ,(2007) , 10.1001/JAMA.298.16.1888