Tolerogenic CD4-8- Dendritic Cells and their Conversion into Immunogenic Ones via TLR9 Signaling

Wei-ping Zheng, Richard A Flavell, The Transcription Factor GATA-3 Is Necessary and Sufficient for Th2 Cytokine Gene Expression in CD4 T Cells Cell. ,vol. 89, pp. 587- 596 ,(1997) , 10.1016/S0092-8674(00)80240-8

Jianlin Gong, David Avigan, Dongshu Chen, Zekui Wu, Shigeo Koido, Masahiro Kashiwaba, Donald Kufe, None, Activation of antitumor cytotoxic T lymphocytes by fusions of human dendritic cells and breast carcinoma cells Proceedings of the National Academy of Sciences of the United States of America. ,vol. 97, pp. 2715- 2718 ,(2000) , 10.1073/PNAS.050587197

A D Santin, S Bellone, A Ravaggi, J J Roman, S Pecorelli, G P Parham, M J Cannon, Induction of tumour-specific CD8(+) cytotoxic T lymphocytes by tumour lysate-pulsed autologous dendritic cells in patients with uterine serous papillary cancer. British Journal of Cancer. ,vol. 86, pp. 151- 157 ,(2002) , 10.1038/SJ.BJC.6600026

James P Lodolce, David L Boone, Sophia Chai, Rachel E Swain, Themistocles Dassopoulos, Shanthi Trettin, Averil Ma, IL-15 Receptor Maintains Lymphoid Homeostasis by Supporting Lymphocyte Homing and Proliferation Immunity. ,vol. 9, pp. 669- 676 ,(1998) , 10.1016/S1074-7613(00)80664-0

Wayne R. Godfrey, Ying G. Ge, Darrin J. Spoden, Bruce L. Levine, Carl H. June, Bruce R. Blazar, Stephen B. Porter, In vitro–expanded human CD4+CD25+ T-regulatory cells can markedly inhibit allogeneic dendritic cell–stimulated MLR cultures Blood. ,vol. 104, pp. 453- 461 ,(2004) , 10.1182/BLOOD-2004-01-0151

Jacques Banchereau, A. Karolina Palucka, Dendritic cells as therapeutic vaccines against cancer Nature Reviews Immunology. ,vol. 5, pp. 296- 306 ,(2005) , 10.1038/NRI1592

Antonius Rolink, Fritz Melchers, Jan Andersson, The SCID but Not the RAG-2 Gene Product Is Required for Sμ–Sε Heavy Chain Class Switching Immunity. ,vol. 5, pp. 319- 330 ,(1996) , 10.1016/S1074-7613(00)80258-7

Helmut Jonuleit, Edgar Schmitt, Kerstin Steinbrink, Alexander H Enk, Dendritic cells as a tool to induce anergic and regulatory T cells. Trends in Immunology. ,vol. 22, pp. 394- 400 ,(2001) , 10.1016/S1471-4906(01)01952-4

Jeremy B. Samon, Ameya Champhekar, Lisa M. Minter, Janice C. Telfer, Lucio Miele, Abdul Fauq, Pritam Das, Todd E. Golde, Barbara A. Osborne, Notch1 and TGFβ1 cooperatively regulate Foxp3 expression and the maintenance of peripheral regulatory T cells Blood. ,vol. 112, pp. 1813- 1821 ,(2008) , 10.1182/BLOOD-2008-03-144980

Xueshu Zhang, Terence Moyana, Mabood Quereshi, Jim Xiang, Conversion of tolerogenic CD4-8- dendritic cells to immunogenic ones inducing efficient antitumor immunity. Cancer Biotherapy and Radiopharmaceuticals. ,vol. 21, pp. 74- 80 ,(2006) , 10.1089/CBR.2006.21.74