Redox signaling associated with thyroid hormone action: perspectives in medical sciences

摘要: Redox signaling, as a consequence of thyroid hormone (TH)-induced energy metabolism, triggers adaptive cellular changes to resume homeostasis. In the liver, this is associated with activation redox-sensitive transcription factors promoting cell protection and survival, including upregulation antioxidant, anti-apoptotic, anti-inflammatory, proliferation responses, concomitant higher supply detoxification potentials. Beneficial effects THs are also observed in extrahepatic tissues against different types noxious stimuli evidenced preclinical studies, well several clinical conditions after restoration normal levels THs. Future additional studies needed order validate diagnostic biomarkers suitable endpoints be endorsed, solve discrepancies concerning low number patients studied type trial TH protocol employed.