Neonatally Induced Allograft Tolerance may be mediated by Serum-borne Factors

摘要: IN 1953, Billingham et al. discovered that mice inoculated neonatally with foreign lymphoid cells can often accept skin grafts from the same strain, indicating they have become “tolerant” to alloantigens of cells1,2. A similar tolerance be induced in adult animals if are rendered chimaeric by inoculation bone marrow after either whole body irradiation or treatment immunosuppressive drugs3,4.