Skeletal morbidity in childhood acute lymphoblastic leukaemia.

摘要: Skeletal morbidity is increasingly being recognized inthese individuals and may occur at diagnosis, during followingtreatment. This an important problem, which result infractures, pain, loss of mobility deformity, with resultant adverseconsequences on quality life. The recognition these complica-tions essential to enable the institution rational strategies formonitoring optimizing bone health.This review will consider many influences that adversely affectbone health in children treated for ALL focus thecommonest abnormality, osteopenia (Fig. 1). Osteopenia charac-terized by a low mineral density (BMD). A BMD duringchildhood lead failure achieve peak mass, whichis thought be major determinant subsequent risk ofosteoporotic fractures later