Quinapril therapy in patients with chronic mitral regurgitation.

摘要: Pre- and afterload reduction is known to have beneficial effects in patients with chronic mitral regurgitation. To date, no controlled study has been reported analyzing the long term influence of angiotensin-converting enzyme inhibitor treatment on Therefore aim this was assess one year inhibition quinapril myocardial performance Twelve moderate severe isolated regurgitation coronary disease angiography were studied under control conditions followed up until therapy (10-20mg/day) using echocardiography simultaneous right heart catheterization, radionuclide ventriculography at rest exercise. As result a significant pre- after regurgitant fraction fell from 0.43 +/- 0.10 before 0.25 0.08 (p = 0.0001), left ventricular end-diastolic volume reduced 146 26 109 24 ml/m2 0.0001) end-systolic decreased 63 43 47 29 0.02). Left ejection averaged 0.59 0.20 rest, increased 0.65 0.21 maximum exercise unchanged therapy. After mass by 15% 0.0004) septal wall thickness 11.8 0.7 10.8 0.8 mm 0.0006). Moreover, there functional improvement nearly NYHA class In conclusion, reduces decreases size thereby demonstrating improvement. addition, these data suggest that might potential delaying valve surgery.