Bradykinin increased the permeability of BTB via NOS/NO/ZONAB-mediating down-regulation of claudin-5 and occludin
作者： Li-bo Liu , Xiao-bai Liu , Jun Ma , Yun-hui Liu , Zhi-qing Li
DOI: 10.1016/J.BBRC.2015.06.082
关键词:
摘要: After demonstrating bradykinin (BK) could increase the permeability of blood-tumor barrier (BTB) via opening tight junction (TJ), and that possible mechanism is unclear, we demonstrated BK expressions eNOS nNOS promote ZONAB translocation into nucleus. NOS inhibitors l-NAME 7-NI effectively block effect on increasing BTB permeability, decreasing claudin-5 occludin promoting ZONAB. Overexpression significantly enhance BK-mediating permeability. Meanwhile, chromatin immunoprecipitation verified interacted with promoter respectively. This study indicated NOS/NO/ZONAB pathway might be involved in BK's BTB.
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sci-hub.se 参考文章(22)
Koichiro Matsukado, Keith L. Black, Shin Nakano, Increased Brain Tumor Microvessel Permeability after Intracarotid Bradykinin Infusion Is Mediated by Nitric Oxide Cancer Research. ,vol. 56, pp. 4027- 4031 ,(1996)
Jun Ma, Ping Wang, Yunhui Liu, Lini Zhao, Zhen Li, Yixue Xue, Krüppel-like factor 4 regulates blood-tumor barrier permeability via ZO-1, occludin and claudin-5. Journal of Cellular Physiology. ,vol. 229, pp. 916- 926 ,(2014) , 10.1002/JCP.24523
Yunhui Liu, Kazuhiro Hashizume, Ken Samoto, Masao Sugita, Nagendra Ningaraj, Kamlesh Asotra, Keith L. Black, Repeated, short-term ischemia augments bradykinin-mediated opening of the blood–tumor barrier in rats with RG2 glioma Neurological Research. ,vol. 23, pp. 631- 640 ,(2001) , 10.1179/016164101101198929
William A. Banks, Shinya Dohgu, Jessica L. Lynch, Melissa A. Fleegal-DeMotta, Michelle A. Erickson, Ryota Nakaoke, Than Q. Vo, Nitric Oxide Isoenzymes Regulate Lipopolysaccharide-Enhanced Insulin Transport across the Blood-Brain Barrier Endocrinology. ,vol. 149, pp. 1514- 1523 ,(2008) , 10.1210/EN.2007-1091
Benjamin K. Hendricks, Aaron A. Cohen-Gadol, James C. Miller, Novel delivery methods bypassing the blood-brain and blood-tumor barriers. Neurosurgical Focus. ,vol. 38, ,(2015) , 10.3171/2015.1.FOCUS14767
Maria S Balda, Karl Matter, The tight junction protein ZO‐1 and an interacting transcription factor regulate ErbB‐2 expression The EMBO Journal. ,vol. 19, pp. 2024- 2033 ,(2000) , 10.1093/EMBOJ/19.9.2024
Florence Lefranc, Niloufar Sadeghi, Isabelle Camby, Thierry Metens, Olivier Dewitte, Robert Kiss, Present and potential future issues in glioblastoma treatment. Expert Review of Anticancer Therapy. ,vol. 6, pp. 719- 732 ,(2006) , 10.1586/14737140.6.5.719
Takanori Inamura, Keith L. Black, Bradykinin Selectively Opens Blood-Tumor Barrier in Experimental Brain Tumors Journal of Cerebral Blood Flow & Metabolism. ,vol. 14, pp. 862- 870 ,(1994) , 10.1038/JCBFM.1994.108
Nikki P. Y. Lee, C. Yan Cheng, Regulation of Sertoli cell tight junction dynamics in the rat testis via the nitric oxide synthase/soluble guanylate cyclase/3',5'-cyclic guanosine monophosphate/protein kinase G signaling pathway: an in vitro study. Endocrinology. ,vol. 144, pp. 3114- 3129 ,(2003) , 10.1210/EN.2002-0167
M. Nie, M. S. Balda, K. Matter, Stress- and Rho-activated ZO-1–associated nucleic acid binding protein binding to p21 mRNA mediates stabilization, translation, and cell survival Proceedings of the National Academy of Sciences of the United States of America. ,vol. 109, pp. 10897- 10902 ,(2012) , 10.1073/PNAS.1118822109