Regeneration und Zelltod von Sinneszellen der Cochlea und des Vestibularorgans
作者： Birgit Mazurek , H. Haupt , A. Szczepek
DOI: 10.1007/978-3-211-75432-0_21
关键词:
摘要: Das Innenohr kann in drei Bereiche unterteilt werden: (1) Cochlea mit Corti-Organ, (2) Gleichgewichtsorgan Bogengangssystem und Crista ampularis sowie (3) Sacculus Utriculus. In allen Bereichen befinden sich Sinneszellen (Haarzellen) Stutzzellen. Die der menschlichen unterteilen ca. 12.000 ausere Haarzellen (AHZ) 3600 innere (IHZ) (Naumann et al. 1994). AHZ sind Reihen die IHZ einer Reihe angeordnet. Sowohl als auch haben Stereozilien. Besonderheit ist, dass sie durch das Motorprotein Prestin kontrahieren bzw. elongieren konnen. Zu den Stutzzellen gehoren Deiters-Zellen, Hensen-Zellen, Pfeilerzellen, Phalangenzellen, Interdental-Zellen Innere Sulkuszellen. spielen fur Regeneration eine bedeutende Rolle.
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sci-hub.st 参考文章(64)
Lisa L. Cunningham, Jonathan I. Matsui, Mark E. Warchol, Edwin W. Rubel, Overexpression of Bcl-2 prevents neomycin-induced hair cell death and caspase-9 activation in the adult mouse utricle in vitro Journal of Neurobiology. ,vol. 60, pp. 89- 100 ,(2004) , 10.1002/NEU.20006
Neil Segil, Ping Chen, p27(Kip1) links cell proliferation to morphogenesis in the developing organ of Corti Development. ,vol. 126, pp. 1581- 1590 ,(1999) , 10.1242/DEV.126.8.1581
Isabelle Joris, G. Majno, Apoptosis, oncosis, and necrosis : an overview of cell death American Journal of Pathology. ,vol. 146, pp. 3- 15 ,(1995)
Paula C. Ashe, Mark D. Berry, Apoptotic signaling cascades Progress in Neuro-Psychopharmacology and Biological Psychiatry. ,vol. 27, pp. 199- 214 ,(2003) , 10.1016/S0278-5846(03)00016-2
P. Walshe, M. Walsh, R. McConn Walsh, Hair cell regeneration in the inner ear: a review Clinical Otolaryngology and Allied Sciences. ,vol. 28, pp. 5- 13 ,(2003) , 10.1046/J.1365-2273.2003.00658.X
Masahiko Izumikawa, Ryosei Minoda, Kohei Kawamoto, Karen A Abrashkin, Donald L Swiderski, David F Dolan, Douglas E Brough, Yehoash Raphael, Auditory hair cell replacement and hearing improvement by Atoh1 gene therapy in deaf mammals Nature Medicine. ,vol. 11, pp. 271- 276 ,(2005) , 10.1038/NM1193
H. Lowenheim, D. N. Furness, J. Kil, C. Zinn, K. Gultig, M. L. Fero, D. Frost, A. W. Gummer, J. M. Roberts, E. W. Rubel, C. M. Hackney, H.-P. Zenner, Gene disruption of p27(Kip1) allows cell proliferation in the postnatal and adult organ of corti. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 96, pp. 4084- 4088 ,(1999) , 10.1073/PNAS.96.7.4084
Sho Kanzaki, Lisa A. Beyer, Donald L. Swiderski, Masahiko Izumikawa, Timo Stöver, Kohei Kawamoto, Yehoash Raphael, p27Kip1 deficiency causes organ of Corti pathology and hearing loss Hearing Research. ,vol. 214, pp. 28- 36 ,(2006) , 10.1016/J.HEARES.2006.01.014
M Duan, F Venail, N Spencer, M Mezzina, Treatment of peripheral sensorineural hearing loss: gene therapy. Gene Therapy. ,vol. 11, ,(2004) , 10.1038/SJ.GT.3302369
Matthew L Fero, Michael Rivkin, Michael Tasch, Peggy Porter, Catherine E Carow, Eduardo Firpo, Kornelia Polyak, Li-Huei Tsai, Virginia Broudy, Roger M Perlmutter, Kenneth Kaushansky, James M Roberts, A Syndrome of Multiorgan Hyperplasia with Features of Gigantism, Tumorigenesis, and Female Sterility in p27Kip1-Deficient Mice Cell. ,vol. 85, pp. 733- 744 ,(1996) , 10.1016/S0092-8674(00)81239-8