Multimodal action of antitumor agents on DNA: The ellipticine series
DOI: 10.1016/0003-9861(87)90463-2
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摘要: Most cytotoxic anticancer agents interact directly or indirectly with nuclear DNA, the ultimate target for this class of compounds. For a given type drug both direct and indirect action at DNA level usually causes various types interference damage. This multimodal mechanism is well illustrated by antitumor drugs in ellipticine series which may bind to through intercalation, undergo covalent binding, generate oxidizing species, interfere catalytic activity topoisomerase II. The these compounds may, therefore, result from alternative events. present review summarizes information obtained on relation between nature drugs' their and/or activity. occurrence topoisomerase-mediated cleavage appears be responsible capability II requires presence an oxidizable phenolic group structure. feature (or related one) shared all acting enzyme.
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