WHO Grade II and III supratentorial hemispheric ependymomas in adults: case series and review of treatment options

摘要: Supratentorial ependymomas and their anaplastic variants are relatively uncommon central nervous system neoplasms that afflict both adults children. Whereas the treatment algorithm in pediatric population is well established, however, adult less defined. In our case series of three patients with supratentorial ependymomas, two had tumors WHO Grade III (anaplastic variant) one tumor II. all patients, gross total resection was achieved. Additional radiation therapy administered patients. Twenty-four-month follow-up 1 yielded no recurrence requirement adjuvant chemotherapy. 2, recurred leptomeningeal gliomatosis by 6 months. Addition platinum-based chemotherapy did not improve long-term survival; patient succumbed to disease after 14 3 (WHO II), required. Tumor recur during 42-month follow-up. experience, achieved hemispheric II or additional for variants. All require initial close serial imaging The role still uncertain but may be necessary younger who have behave more like ependymomas.