摘要: DNA mismatch repair (MMR) corrects mismatched base pairs mainly caused by replication errors. The fundamental mechanisms and proteins involved in the early reactions of MMR are highly conserved almost all organisms ranging from bacteria to human. significance this system is also indicated fact that defects cause human hereditary nonpolyposis colon cancers as well sporadic tumors. To date, 2 types MMRs known: type Escherichia coli type. basic features former expected be universal among vast majority including most bacteria. Here, I review molecular eukaryotic bacterial MMR, emphasizing on similarities between them.
hindawi.com参考文章(122)
Taisuke Wakamatsu, Yoshiaki Kitamura, Yutaro Kotera, Noriko Nakagawa, Seiki Kuramitsu, Ryoji Masui, Structure of RecJ exonuclease defines its specificity for single-stranded DNA Journal of Biological Chemistry. ,vol. 285, pp. 9762- 9769 ,(2010) , 10.1074/JBC.M109.096487
M. A. Calmann, Separation of mutation avoidance and antirecombination functions in an Escherichia coli mutS mutant Nucleic Acids Research. ,vol. 33, pp. 1193- 1200 ,(2005) , 10.1093/NAR/GKI263
Ken-ichi Yoshioka, Yoshiko Yoshioka, Peggy Hsieh, ATR Kinase Activation Mediated by MutSα and MutLα in Response to Cytotoxic O6-Methylguanine Adducts Molecular Cell. ,vol. 22, pp. 501- 510 ,(2006) , 10.1016/J.MOLCEL.2006.04.023
Marc L. Mendillo, Victoria V. Hargreaves, Jonathan W. Jamison, Ashley O. Mo, Sheng Li, Christopher D. Putnam, Virgil L. Woods, Richard D. Kolodner, A conserved MutS homolog connector domain interface interacts with MutL homologs Proceedings of the National Academy of Sciences of the United States of America. ,vol. 106, pp. 22223- 22228 ,(2009) , 10.1073/PNAS.0912250106
N O Kaplan, S P Colowick, Jagannathan, M D Joshi, Methods in Enzymology , Vol University Of Nairobi. ,(1966)
Meindert H. Lamers, Anastassis Perrakis, Jacqueline H. Enzlin, Herrie H. K. Winterwerp, Niels de Wind, Titia K. Sixma, The crystal structure of DNA mismatch repair protein MutS binding to a G x T mismatch. Nature. ,vol. 407, pp. 711- 717 ,(2000) , 10.1038/35037523
P. Macpherson, 8-oxoguanine incorporation into DNA repeats in vitro and mismatch recognition by MutSalpha. Nucleic Acids Research. ,vol. 33, pp. 5094- 5105 ,(2005) , 10.1093/NAR/GKI813
F. Längle-Rouault, G. Maenhaut-Michel, M. Radman, GATC sequences, DNA nicks and the MutH function in Escherichia coli mismatch repair. The EMBO Journal. ,vol. 6, pp. 1121- 1127 ,(1987) , 10.1002/J.1460-2075.1987.TB04867.X
Steven M. Lipkin, Victoria Wang, Russell Jacoby, Sharmila Banerjee-Basu, Andreas D. Baxevanis, Henry T. Lynch, Rosemary M. Elliott, Francis S. Collins, MLH3: a DNA mismatch repair gene associated with mammalian microsatellite instability. Nature Genetics. ,vol. 24, pp. 27- 35 ,(2000) , 10.1038/71643
P Modrich, Methyl-directed DNA mismatch correction. Journal of Biological Chemistry. ,vol. 264, pp. 6597- 6600 ,(1989) , 10.1016/S0021-9258(18)83467-6