Pharmacokinetic studies on Ro 15-1788, a benzodiazepine receptor ligand, in the brain of the rat.
作者： Richard G. Lister , David J. Greenblatt , Darrell R. Abernethy , Sandra E. File
DOI: 10.1016/0006-8993(84)90752-2
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摘要: Methods for determining Ro 15-1788 in brain tissue were developed using gas chromatography with nitrogen-phosphorus detection, and reverse-phase high performance liquid chromatography. Application of the methods to pharmacokinetic studies rat found elimination half-life from be 16 min. was undetectable plasma at time points studied. Concentrations reduced if chlordiazepoxide coadministered.
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