BEK and FLG, two receptors to members of the FGF family, are amplified in subsets of human breast cancers.

摘要: Abstract Tumor DNA samples from 387 breast carcinomas have been investigated for amplification of BEK and FLG genes, both which shown to code cell surface receptors FGFs. were found amplified in 11.5 12.7% tumors respectively. Statistical analysis, performed on the subset 297 primary cancers without presurgical therapy, showed a trend preferential patients above 50 years (P = 0.055), whereas could significantly be correlated with nodal involvement 0.032) seemed prevalent steroid hormones receptor positive tumors. Since same previously analysed MYC, ERBB2 HST/INT2/BCL1 possible associations amplifications looked for. was MYC HST/INT2/BLC1. The these two FGF genes may therefore represent additional steps molecular phenotyping cancer.