Quoi de neuf pour l’adénocarcinome colorectal depuis la fin du dernier millénaire ?

作者: T. Aparicio

DOI: 10.1007/S11725-015-0562-X

关键词:

摘要: Des progres important ont ete realises en 15 ans dans la prise charge du cancer colorectal. Un depistage organise a mis place France et va etre encore ameliore 2015. La caracterisation des formes familiales est devenue plus facile grâce aux consultations d’oncogenetique. therapeutiques obtenus ce qui concerne chimiotherapie. En cas de forme localisee, les indications chimiotherapie sont mieux definies l’association fluoropyrimidine + oxaliplatine permet guerir majorite patients apres exerese chirurgicale meme d’envahissement ganglionnaire. tumeurs metastatiques survie augmente mesure que nouveaux medicaments etaient disponibles. D’autre part, limites chirurgie metastases recule permettant guerison au stade metastatique. A l’avenir, generalisation diagnostics moleculaires devrait permettre d’optimiser traitements. L’amelioration âges reste un defi relever.

参考文章(57)
Ramon Salazar, Paul Roepman, Gabriel Capella, Victor Moreno, Iris Simon, Christa Dreezen, Adriana Lopez-Doriga, Cristina Santos, Corrie Marijnen, Johan Westerga, Sjoerd Bruin, David Kerr, Peter Kuppen, Cornelis van de Velde, Hans Morreau, Loes Van Velthuysen, Annuska M. Glas, Laura J. Van't Veer, Rob Tollenaar, Gene Expression Signature to Improve Prognosis Prediction of Stage II and III Colorectal Cancer Journal of Clinical Oncology. ,vol. 29, pp. 17- 24 ,(2011) , 10.1200/JCO.2010.30.1077
Hans F A Vasen, Ignacio Blanco, Katja Aktan-Collan, Jessica P Gopie, Angel Alonso, Stefan Aretz, Inge Bernstein, Lucio Bertario, John Burn, Gabriel Capella, Chrystelle Colas, Christoph Engel, Ian M Frayling, Maurizio Genuardi, Karl Heinimann, Frederik J Hes, Shirley V Hodgson, John A Karagiannis, Fiona Lalloo, Annika Lindblom, Jukka-Pekka Mecklin, Pal Møller, Torben Myrhoj, Fokko M Nagengast, Yann Parc, Maurizio Ponz de Leon, Laura Renkonen-Sinisalo, Julian R Sampson, Astrid Stormorken, Rolf H Sijmons, Sabine Tejpar, Huw J W Thomas, Nils Rahner, Juul T Wijnen, Heikki Juhani Järvinen, Gabriela Möslein, Revised guidelines for the clinical management of Lynch syndrome (HNPCC): recommendations by a group of European experts Gut. ,vol. 62, pp. 812- 823 ,(2013) , 10.1136/GUTJNL-2012-304356
David Cunningham, Istvan Lang, Eugenio Marcuello, Vito Lorusso, Janja Ocvirk, Dong Bok Shin, Derek Jonker, Stuart Osborne, Niko Andre, Daniel Waterkamp, Mark P Saunders, Bevacizumab plus capecitabine versus capecitabine alone in elderly patients with previously untreated metastatic colorectal cancer (AVEX): an open-label, randomised phase 3 trial Lancet Oncology. ,vol. 14, pp. 1077- 1085 ,(2013) , 10.1016/S1470-2045(13)70154-2
Daniel J. Sargent, Silvia Marsoni, Genevieve Monges, Stephen N. Thibodeau, Roberto Labianca, Stanley R. Hamilton, Amy J. French, Brian Kabat, Nathan R. Foster, Valter Torri, Christine Ribic, Axel Grothey, Malcolm Moore, Alberto Zaniboni, Jean-Francois Seitz, Frank Sinicrope, Steven Gallinger, Defective Mismatch Repair As a Predictive Marker for Lack of Efficacy of Fluorouracil-Based Adjuvant Therapy in Colon Cancer Journal of Clinical Oncology. ,vol. 28, pp. 3219- 3226 ,(2010) , 10.1200/JCO.2009.27.1825
Thierry André, Corrado Boni, Lamia Mounedji-Boudiaf, Matilde Navarro, Josep Tabernero, Tamas Hickish, Clare Topham, Marta Zaninelli, Philip Clingan, John Bridgewater, Isabelle Tabah-Fisch, Aimery de Gramont, None, Oxaliplatin, Fluorouracil, and Leucovorin as Adjuvant Treatment for Colon Cancer The New England Journal of Medicine. ,vol. 350, pp. 2343- 2351 ,(2004) , 10.1056/NEJMOA032709
Yong Sang Hong, Byung-Ho Nam, Kyu-Pyo Kim, Jae-Lyun Lee, Joon Oh Park, Young Suk Park, Sun Young Kim, Tae-You Kim, Jee Hyun Kim, Joong Bae Ahn, Kyung Hae Jung, Tae Won Kim, Adjuvant chemotherapy with oxaliplatin/5-fluorouracil/leucovorin (FOLFOX) versus 5-fluorouracil/leucovorin (FL) for rectal cancer patients whose postoperative yp stage 2 or 3 after preoperative chemoradiotherapy: Updated results of 3-year disease-free survival from a randomized phase II study (The ADORE). Journal of Clinical Oncology. ,vol. 32, pp. 3502- 3502 ,(2014) , 10.1200/JCO.2014.32.15_SUPPL.3502
S Marsoni, None, Efficacy of adjuvant fluorouracil and folinic acid in colon cancer The Lancet. ,vol. 345, pp. 939- 944 ,(1995)
Leonardo Ventura, Paola Mantellini, Grazia Grazzini, Guido Castiglione, Carlotta Buzzoni, Tiziana Rubeca, Claudio Sacchettini, Eugenio Paci, Marco Zappa, The impact of immunochemical faecal occult blood testing on colorectal cancer incidence. Digestive and Liver Disease. ,vol. 46, pp. 82- 86 ,(2014) , 10.1016/J.DLD.2013.07.017
Thomas Aparicio, Olivier Schischmanoff, Cecile Poupardin, Nadem Soufir, Celine Angelakov, Christophe Barrat, Vincent Levy, Laurence Choudat, Joel Cucherousset, Marouane Boubaya, Christine Lagorce, Gaetan Des Guetz, Philippe Wind, Robert Benamouzig, Deficient mismatch repair phenotype is a prognostic factor for colorectal cancer in elderly patients Digestive and Liver Disease. ,vol. 45, pp. 245- 250 ,(2013) , 10.1016/J.DLD.2012.09.013