Assessment of response to chemoradiation therapy in rectal cancer using MR volumetry based on diffusion-weighted data sets: a preliminary report

摘要: This study evaluated the feasibility of magnetic resonance (MR) volumetry using a diffusion-weighted data set (VDWI) and compared it with conventional T2-weighted (VC) in patients affected by rectal cancer treated chemoradiation therapy (CHRT). Fourteen biopsy diagnosis underwent MR examination before after CHRT. images were used to extrapolate VC. A (DW) sequence was acquired [spin-echo echo-planar imaging (SE-DW-EPI)] b-value 800 s/mm2 volume calculated semiautomatic segmentation tumour hyperintensity. Two radiologists independently assessed volumes analysed order establish interobserver agreement compare correlate regression grade (TRG), as evaluable at pathological surgical specimen. Interobserver 0.977 [(95% confidence interval (CI) 0.954–0.989) 0.956 (95% CI 0.905–0.980) for VC VDWI 0.964 0.896–0.988) 0.271 CI-0.267 0.686) between The correlation TRG was, respectively, rho = 0.597 (p<0.05) r2=0.156 (p=0.162) rho=0.847 (p<0.001). seems be promising tool assessing response CHRT cancer. Further studies on large series are needed refine technique evaluate its potential predictive value.