Nano-Size Effect of Hyperbranched Polyglycerol-Grafted Fe3O4 Nanoparticles
作者： Liang Wang , Dan Su , Lai Jiang , Xuequan Feng
DOI: 10.1080/1539445X.2014.912222
关键词:
摘要: Hyperbranched polyglycerol-grafted Fe3O4 nanoparticles (HPG-grafted MNPs) are newly developed MRI contrast agents with good stability, dispersibility, and biocompatibility. Their magnetic, cell uptake properties may be changed when their size varies. In this study, HPG-grafted MNPs ranging from 8 to 10, 13, 15 nm were successfully synthesized via a facile one-pot reaction using ferric oxalate pentahydrate as the precursor. With increase of particle size, show increasing trends in saturation magnetization, transverse relaxivities (R2), R2/R1 ratio, uptake. MTT assays indicated that defferent sizes did not possess significant cytotoxicity toward mouse macrophages 3T3 fibroblasts. Furthermore, vivo experiments carried out 8-nm injected into live rabbit. Our results demonstrate MNPs, which can synthetically controlled, played an important role tuning magneti...
sci-hub.se 参考文章(50)
Lisette H. Deddens, Geralda A. F. van Tilborg, Annette van der Toorn, Helga E. de Vries, Rick M. Dijkhuizen, PECAM‐1‐targeted micron‐sized particles of iron oxide as MRI contrast agent for detection of vascular remodeling after cerebral ischemia Contrast Media & Molecular Imaging. ,vol. 8, pp. 393- 401 ,(2013) , 10.1002/CMMI.1536
Eric D. Smolensky, Hee-Yun E. Park, Thelma S. Berquó, Valérie C. Pierre, Surface functionalization of magnetic iron oxide nanoparticles for MRI applications – effect of anchoring group and ligand exchange protocol Contrast Media & Molecular Imaging. ,vol. 6, pp. 189- 199 ,(2010) , 10.1002/CMMI.417
Mei Lin, Dongsheng Zhang, Junxing Huang, Jia Zhang, Wei Xiao, Hong Yu, Lixin Zhang, Jun Ye, The anti-hepatoma effect of nanosized Mn-Zn ferrite magnetic fluid hyperthermia associated with radiation in vitro and in vivo. Nanotechnology. ,vol. 24, pp. 255101- ,(2013) , 10.1088/0957-4484/24/25/255101
Esther Amstad, Marcus Textor, Erik Reimhult, Stabilization and functionalization of iron oxide nanoparticles for biomedical applications Nanoscale. ,vol. 3, pp. 2819- 2843 ,(2011) , 10.1039/C1NR10173K
Ruirui Qiao, Qiaojuan Jia, Sabine Hüwel, Rui Xia, Ting Liu, Fabao Gao, Hans-Joachim Galla, Mingyuan Gao, Receptor-mediated delivery of magnetic nanoparticles across the blood-brain barrier. ACS Nano. ,vol. 6, pp. 3304- 3310 ,(2012) , 10.1021/NN300240P
Liang Wang, K. G. Neoh, E. T. Kang, Borys Shuter, Shih-Chang Wang, Superparamagnetic Hyperbranched Polyglycerol-Grafted Fe3O4Nanoparticles as a Novel Magnetic Resonance Imaging Contrast Agent: An In Vitro Assessment Advanced Functional Materials. ,vol. 19, pp. 2615- 2622 ,(2009) , 10.1002/ADFM.200801689
Shy Chyi Wuang, Koon Gee Neoh, E‐T Kang, Daniel W Pack, Deborah E Leckband, Heparinized Magnetic Nanoparticles: In-Vitro Assessment for Biomedical Applications† Advanced Functional Materials. ,vol. 16, pp. 1723- 1730 ,(2006) , 10.1002/ADFM.200500879
Helen Vallhov, Susanne Gabrielsson, Maria Strømme, Annika Scheynius, Alfonso E. Garcia-Bennett, Mesoporous silica particles induce size dependent effects on human dendritic cells. Nano Letters. ,vol. 7, pp. 3576- 3582 ,(2007) , 10.1021/NL0714785
Nathan Kohler, Glen E. Fryxell, Miqin Zhang, A bifunctional poly(ethylene glycol) silane immobilized on metallic oxide-based nanoparticles for conjugation with cell targeting agents. Journal of the American Chemical Society. ,vol. 126, pp. 7206- 7211 ,(2004) , 10.1021/JA049195R
Mohammed Ibrahim Shukoor, Filipe Natalio, Helen Annal Therese, Muhammad Nawaz Tahir, Vadim Ksenofontov, Martin Panthöfer, Marc Eberhardt, Patrick Theato, Heinz Christoph Schröder, Werner EG Müller, Wolfgang Tremel, None, Fabrication of a Silica Coating on Magnetic γ-Fe2O3 Nanoparticles by an Immobilized Enzyme Chemistry of Materials. ,vol. 20, pp. 3567- 3573 ,(2008) , 10.1021/CM7029954