Common Denominators of Self-renewal and Malignancy in Neural Stem Cells and Glioma

摘要: Regulation of neural stem cell number needs to be tightly controlled. Mutations affecting cells or progenitor may result in uncontrolled proliferation and ultimately cancer. A growing body evidence suggests that this mechanism underlies the genesis several brain tumors, e.g. gliomas. The most malignant form is called glioblastoma multiforme unfortunately its prognosis remains poor. concept tumor-causing cell-like cells, also cancer solid tumors has attracted a lot interest over last 5–10 years. glioma-initiating bearing characteristics been proposed as origin glioma, with ability seed new through capacity evade chemotherapy irradiation. This would unique feature for not shared by bulk tumor cells. Neural progenitors have common traits, such sustained highly efficient migratory brain. There are similarities between then neurogenic niche where adult reside, tumorigenic niche. These include interactions extracellular matrix, many matrix components deregulated glioma. signaling pathways mutated glioma general important regulate proliferation/self renewal, differentiation, migration survival. Molecular changes these due mutations associated development so present therapy targets. Novel molecular classification gives hope more stratified treatment, we hopefully on threshold patient-specific treatments which finally change outcome devastating disease.