Rationale and Application of PEGylated Lipid-Based System for Advanced Target Delivery of siRNA

Carol A. Sledz, Michelle Holko, Michael J. de Veer, Robert H. Silverman, Bryan R.G. Williams, Activation of the interferon system by short-interfering RNAs Nature Cell Biology. ,vol. 5, pp. 834- 839 ,(2003) , 10.1038/NCB1038

Derek W. Bartlett, Mark E. Davis, Physicochemical and biological characterization of targeted, nucleic acid-containing nanoparticles Bioconjugate Chemistry. ,vol. 18, pp. 456- 468 ,(2007) , 10.1021/BC0603539

Dileep P. Vangasseri, Zhengrong Cui, Weihsu Chen, David A. Hokey, Louis D. Falo, Leaf Huang, Immunostimulation of dendritic cells by cationic liposomes. Molecular Membrane Biology. ,vol. 23, pp. 385- 395 ,(2006) , 10.1080/09687860600790537

Varun Kumar, June Qin, Yongfeng Jiang, Richard G Duncan, Benjamin Brigham, Shannon Fishman, Jayaprakash K Nair, Akin Akinc, Scott A Barros, Pia V Kasperkovitz, Shielding of Lipid Nanoparticles for siRNA Delivery: Impact on Physicochemical Properties, Cytokine Induction, and Efficacy Molecular therapy. Nucleic acids. ,vol. 3, ,(2014) , 10.1038/MTNA.2014.61

Alan J Bridge, Stephanie Pebernard, Annick Ducraux, Anne-Laure Nicoulaz, Richard Iggo, Induction of an interferon response by RNAi vectors in mammalian cells Nature Genetics. ,vol. 34, pp. 263- 264 ,(2003) , 10.1038/NG1173

Yu-Cheng Tseng, Subho Mozumdar, Leaf Huang, Lipid-based systemic delivery of siRNA Advanced Drug Delivery Reviews. ,vol. 61, pp. 721- 731 ,(2009) , 10.1016/J.ADDR.2009.03.003

Mario C Filion, Nigel C Phillips, Toxicity and immunomodulatory activity of liposomal vectors formulated with cationic lipids toward immune effector cells. Biochimica et Biophysica Acta. ,vol. 1329, pp. 345- 356 ,(1997) , 10.1016/S0005-2736(97)00126-0

Yvonne Perrie, Peter M. Frederik, Gregory Gregoriadis, Liposome-mediated DNA vaccination: the effect of vesicle composition. Vaccine. ,vol. 19, pp. 3301- 3310 ,(2001) , 10.1016/S0264-410X(00)00432-1

Ronald K. Scheule, Judith A. St. George, Rebecca G. Bagley, John Marshall, Johanne M. Kaplan, Geoffrey Y. Akita, Kathryn X. Wang, Edward R. Lee, David J. Harris, Canwen Jiang, Nelson S. Yew, Alan E. Smith, Seng H. Cheng, BASIS OF PULMONARY TOXICITY ASSOCIATED WITH CATIONIC LIPID-MEDIATED GENE TRANSFER TO THE MAMMALIAN LUNG Human Gene Therapy. ,vol. 8, pp. 689- 707 ,(1997) , 10.1089/HUM.1997.8.6-689

Lee Adam Wheeler, Radiana Trifonova, Vladimir Vrbanac, Emre Basar, Shannon McKernan, Zhan Xu, Edward Seung, Maud Deruaz, Tim Dudek, Jon Ivar Einarsson, Linda Yang, Todd M. Allen, Andrew D. Luster, Andrew M. Tager, Derek M. Dykxhoorn, Judy Lieberman, Inhibition of HIV transmission in human cervicovaginal explants and humanized mice using CD4 aptamer-siRNA chimeras Journal of Clinical Investigation. ,vol. 121, pp. 2401- 2412 ,(2011) , 10.1172/JCI45876