The inflammasome and lupus: another innate immune mechanism contributing to disease pathogenesis?

摘要: The role of innate immunity in systemic lupus erythematosus (SLE) has been a rapidly expanding area research over the last decade. Included this rubric is concept that activation inflammasome, molecular complex activates caspase-1 and turn cytokines IL-1β IL-18, important pathogenesis. This review will summarize recent discoveries exploring inflammasome machinery SLE. Immune complexes can activate NLRP3 SLE-derived macrophages are hyper-responsive to immune stimuli, leading enhanced production inflammatory cytokines. Work several murine models suggests an for mediating nephritis. Caspase-1, central enzyme essential development type I interferon responses, autoantibody production, nephritis pristane model lupus. absence melanoma 2 may have protective pathogenic roles SLE. Recent evidence dysregulated SLE, plays promotion organ damage, mediate cross-talk between environmental triggers Further should focus on whether inhibition components serve as viable target therapeutic SLE.