Interactive effect of cigarettes and coffee on daytime systolic blood pressure in patients with mild essential hypertension. HARVEST Study Group (Italy). Hypertension Ambulatory Recording VEnetia STudy.

摘要: Objective : To test the hypothesis that moderate smoking (fewer than 20 cigarettes/day) and coffee consumption have an interactive effect on ambulatory blood pressure. Design A case-control study. Setting Patients in multicentre Hypertension Ambulatory Venetia Study, northeastern Italy. Subjects Six hundred forty-three men 244 women with borderline-to-mild hypertension had never been treated, subdivided according to their status (non-smokers versus smokers) habitual of (0, 1-3, or 4+ cups/day). Main outcome measures Office pressure, urinary adrenaline noradrenaline levels status, interaction. Results In men, daytime systolic pressure (SBP) was significantly higher smokers non-smokers drinkers others. Moreover, two-way analysis covariance revealed a significant interaction between SBP who drank cups/day 6.0 mmHg abstained from coffee. Conversely, office lower similar Coffee adrenaline. Similar results were obtained women. Conclusions contrast what is shown by measurement, mild those do not drink Cigarettes young patients essential hypertension.