Quantum proteolysis by neutrophils: implications for pulmonary emphysema in alpha 1-antitrypsin deficiency.

作者: Edward J. Campbell , Melody A. Campbell , Steve S. Boukedes , Caroline A. Owen

DOI: 10.1172/JCI6092

关键词:

摘要: Traditional enzyme kinetics provide a poor explanation for the increased risk of lung injury in α 1 -antitrypsin (AAT) deficiency. Millimolar concentrations of leukocyte elastase, when …

参考文章(52)
A Janoff, Elastases and emphysema. Current assessment of the protease-antiprotease hypothesis. The American review of respiratory disease. ,vol. 132, pp. 417- 433 ,(1985) , 10.1164/ARRD.1985.132.2.417
Shapiro Sd, The pathogenesis of emphysema: the elastase:antielastase hypothesis 30 years later. Proceedings of the Association of American Physicians. ,vol. 107, pp. 346- 352 ,(1995)
Donal J. O’Donoghue, Mary Guickian, Gillian Blundell, Robin J. Winney, Alpha-1-Proteinase Inhibitor and Pulmonary Haemorrhage in Systemic Vasculitis Advances in Experimental Medicine and Biology. ,vol. 336, pp. 331- 335 ,(1993) , 10.1007/978-1-4757-9182-2_54
W P Daniel Su, Kevin C. Smith, Mark R. Pittelkow, R K Winkelmann, Alpha 1-antitrypsin deficiency panniculitis: a histopathologic and immunopathologic study of four cases. American Journal of Dermatopathology. ,vol. 9, pp. 483- 490 ,(1987) , 10.1097/00000372-198712000-00003
G S Mudholkar, D M Speers, J W Shigeoka, C C Lin, W J Hall, R W Hyde, R H Schwartz, The prevalence of alpha-antitrypsin heterozygotes (Pi MZ) in patients with obstructive pulmonary disease. The American review of respiratory disease. ,vol. 114, pp. 1077- 1084 ,(1976) , 10.1164/ARRD.1976.114.6.1077
John Crank, The mathematics of diffusion ,(1956)
G. Weinbaum, E. Murer, N. Laudenslager, U. Kucich, V. V. Damiano, Ultrastructural quantitation of peroxidase- and elastase-containing granules in human neutrophils. American Journal of Pathology. ,vol. 131, pp. 235- 245 ,(1988)
Kjell Ohlsson, Inge Odsson, The Neutral Proteases of Human Granulocytes FEBS Journal. ,vol. 42, pp. 519- 527 ,(1974) , 10.1111/J.1432-1033.1974.TB03367.X